Synthesis of Spirocyclic Amines by Using Dipolar Cycloadditions of Nitrones
نویسندگان
چکیده
منابع مشابه
synthesis of amido alkylnaphthols using nano-magnetic particles and surfactants
we used dbsa and nano-magnetic for the synthesis of amido alkylnaphtols.
15 صفحه اولNitrones as dipoles for rapid strain-promoted 1,3-dipolar cycloadditions with cyclooctynes.
Strain-promoted cycloadditions of nitrones with cyclooctynes (k(2) = 1.5 M(-1) s(-1) at 25 degrees C) are up to 25 times more rapid than comparable reactions of azides.
متن کامل1,3-Dipolar cycloadditions: applications to the synthesis of antiviral agents.
In the present perspective the advances and real possibilities of 1,3-dipolar cycloadditions as key steps in the total synthesis of virus inhibitors are described. Azides, nitrones, and azomethine ylides are the most appropriate 1,3-dipoles for the synthesis of privileged structures with the highest biological responses against viruses.
متن کاملnano-rods zno as an efficient catalyst for the synthesis of chromene phosphonates, direct amidation and formylation of amines
چکیده ندارد.
Trimethylsilyl chloride promoted synthesis of α-branched amines by nucleophilic addition of organozinc halides to nitrones.
A general procedure for the nucleophilic addition of organozinc halides with nitrones in the presence of trimethylsilyl chloride has been developed. Trimethylsilyl chloride was found to be both an indispensable reaction promoter and a ready hydroxylamine protective agent in these reactions. The produced O-(trimethylsilyl)hydroxylamines can be easily reduced into corresponding amines just by a z...
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ژورنال
عنوان ژورنال: The Journal of Organic Chemistry
سال: 2017
ISSN: 0022-3263,1520-6904
DOI: 10.1021/acs.joc.7b00959